Scholarly Activities

Resident Awards & Honors

2022 AUR Virtual Vydareny Imaging Competition Winners

2022 Awards & Honors

2022 ARRS Scientific Exhibit Summa Cum Laude Award - Christine Boone, MD, PhD
2022 Radiographics Trainee Editorial Board - Melina Hosseiny, MD
2022 Editor-in-Chief of the newsletter and Innovation Officer for the executive committee of the Society of Abdominal Radiology Resident and Fellow Section (SAR-RFS)- Melina Hosseiny, MD
2022 SIR Resident Research Award - Christine Boone, MD, PhD
2022 SIR Featured Abstract - Christine Boone, MD, PhD
2022 Panacea Financial Foundation's Resident/Fellow Grant - Christine Boone, MD, PhD
2022 AUR Vydarney Imaging Interpretation Competition Champions

2021 Awards & Honors

2021 RSNA Meeting Trainee Research Prize - Christine Boone, MD, PhD

2020 Awards & Honors

2020 RSNA Annual Meeting RadioGraphics Resident Subspecialty Review Panel Member - Alexandra (Ola) Besser, MD, PhD
2020 Radiology In Training Editorial Board Member - Adam Searleman, MD, PhD
2020 DOD Peer Reviewed Cancer Research Program (PRCRP) Idea Award with Special Focus (co-authored grant) - Christine Boone, MD, PhD
2020 SIR Foundation Pilot Research Grant - Christine Boone, MD, PhD
2020 RSNA Research Resident/Fellow Grant - Brian Hurt, MD
2020 RSNA Research Resident/Fellow Grant - Julie An, MD
2020 UC San Diego Resident Physician Council Seed Grant - Adam Robinson, MD
2020 UC San Diego George Leopold Award for Exceptional Radiology Education - Amy Maduram, MD and Lindsey Negrete, MD
2020 UC San Diego Elliot C. Lasser Award for Excellence in Research - Zachary Berman, MD
2020 UC San Diego John R. Amberg Award for Clinical Excellence - Raymond Melikian, MD
2020 UC San Diego Imaging Services Outstanding Resident of the Year Award - Amy Maduram, MD

2019 Awards & Honors

2019 RSNA Research Resident/Fellow Grant - Tyler Mandt, MD
2019 AUR/RSNA Introductory to Academic Medicine Award- Tara Retson, MD, PhD
2019 ACR AUR Research Scholarship - Soudabeh Fazeli Dehkordy, MD, MPH

2018 Awards & Honors

2018 AUR/RSNA Introductory to Academic Medicine Award- Cheng William Hong, MD
2018 RSNA Research Resident/Fellow Grant - Tara Retson, MD, PhD
2018 RSNA Research Resident/Fellow Grant - Kang Wang, MD, PhD
2018 RSNA Research Resident/Fellow Grant - Ghiam Yamin, MD, PhD
2018 RSNA Research Trainee Prize - Soudabeh Fazeli Dehkordy, MD, MPH
2018 ARRS President's Award - Tara Retson, MD, PhD

2017 Awards & Honors

2017 RSNA Research Resident/Fellow Grant - Cheng William Hong, MD
2017 RSNA Research Resident/Fellow Grant - Soudabeh Fazeli Dehkordy, MD, MPH
2017 SAR Alexander R. Margoulis Award - Soudabeh Fazeli Dehkordy, MD, MPH
2017 RSNA Roentgen Resident Research Award- Chris Malone, MD

Recent Resident Publications

Unsupervised Learning Identifies CT Measurements as Primary Drivers of Progression, Exacerbation, and Mortality in COPD. Yuan NF, Hasenstab K, Retson T, Conrad DJ, Lynch DA, Hsiao A. Ann Am Thorac Soc. 2022 Jul 13. doi: 10.1513/AnnalsATS.202110-1127OC. Online ahead of print. PMID: 35830591

Tri-Compartmental Restriction Spectrum Imaging Breast Model Distinguishes Malignant Lesions from Benign Lesions and Healthy Tissue on Diffusion-Weighted Imaging. Besser AH, Fang LK, Tong MW, Sjaastad Andreassen MM, Ojeda-Fournier H, Conlin CC, Loubrie S, Seibert TM, Hahn ME, Kuperman JM, Wallace AM, Dale AM, Rodríguez-Soto AE, Rakow-Penner RA. Cancers (Basel). 2022 Jun 30;14(13):3200. doi: 10.3390/cancers14133200. PMID: 35804972

Renovascular involvement of systemic vascular disease: a pictorial review. Qaseem Y, Cassidy F, Aganovic L, Purysko A, Mirza S, Vahdat N. Abdom Radiol (NY). 2022 Jul 7:1-15. doi: 10.1007/s00261-022-03591-5. Online ahead of print. PMID: 35796773

Cowpea Mosaic Virus and Natural Killer Cell Agonism for In Situ Cancer Vaccination. Koellhoffer EC, Steinmetz NF. Nano Lett. 2022 Jul 13;22(13):5348-5356. doi: 10.1021/acs.nanolett.2c01328. Epub 2022 Jun 17. PMID: 35713326

Magnetic resonance imaging appearance of breaststroker's knee. Cheng KY, Chambers H, Dwek JR. Pediatr Radiol. 2022 Jun 8. doi: 10.1007/s00247-022-05407-6. Online ahead of print. PMID: 35672477

May-Thurner syndrome in patients with postural orthostatic tachycardia syndrome and Ehlers-Danlos syndrome: a case series. Ormiston CK, Padilla E, Van DT, Boone C, You S, Roberts AC, Hsiao A, Taub PR. Eur Heart J Case Rep. 2022 Apr 9;6(4):ytac161. doi: 10.1093/ehjcr/ytac161. eCollection 2022 Apr. PMID: 35620060

Point-of-care magnetic resonance technology to measure liver fat: Phantom and first-in-human pilot study. Barahman M, Grunvald E, Prado PJ, Bussandri A, Henderson WC, Wolfson T, Fowler KJ, Sirlin CB. Magn Reson Med. 2022 May 25. doi: 10.1002/mrm.29304. Online ahead of print. PMID: 35611691

Cerebral perfusion in posterior reversible encephalopathy syndrome measured with arterial spin labeling MRI. Fazeli S, Noorbakhsh A, Imbesi SG, Bolar DS. Neuroimage Clin. 2022 Apr 30;35:103017. doi: 10.1016/j.nicl.2022.103017. Online ahead of print. PMID: 35584601

AcidoCEST-UTE MRI Reveals an Acidic Microenvironment in Knee Osteoarthritis. Lombardi AF, Ma Y, Jang H, Jerban S, Tang Q, Searleman AC, Meyer RS, Du J, Chang EY. Int J Mol Sci. 2022 Apr 18;23(8):4466. doi: 10.3390/ijms23084466. PMID: 35457284

18F-FES PET/CT Improves the Detection of Intraorbital Metastases in Estrogen-Receptor-Positive Breast Cancer: Two Representative Cases and Review of the Literature. Bodapati S, Abraham P, Chen A, Guilbault D, McDonald M, Matro J, Shatsky R, Obrzut S. Tomography. 2022 Apr 7;8(2):1060-1065. doi: 10.3390/tomography8020086. PMID: 35448720

Utility of Cone-Beam CT for Bronchial Artery Embolization and Chemoinfusion: A Single-Institution Retrospective Case Series. Liu MY, Rose SC, Loh A, Taddonio M, Redmond JW, Meisinger QC, Minocha J, Berman ZT. Cardiovasc Intervent Radiol. 2022 Jun;45(6):834-840. doi: 10.1007/s00270-022-03148-5. Epub 2022 Apr 19. PMID: 35441243

A case of percutaneous cryoablation complicated by subcapsular hemorrhage managed conservatively. Dubinin AM, Rivera-Sanfeliz G, Derweesh I, Duncan D. Radiol Case Rep. 2022 Apr 8;17(6):2014-2017. doi: 10.1016/j.radcr.2022.03.061. eCollection 2022 Jun. PMID: 35432672

Automated Deep Learning Analysis for Quality Improvement of CT Pulmonary Angiography. Hahn LD, Hall K, Alebdi T, Kligerman SJ, Hsiao A. Radiol Artif Intell. 2022 Feb 23;4(2):e210162. doi: 10.1148/ryai.210162. eCollection 2022 Mar. PMID: 35391776

Reader Perceptions and Impact of AI on CT Assessment of Air Trapping. Retson TA, Hasenstab KA, Kligerman SJ, Jacobs KE, Yen AC, Brouha SS, Hahn LD, Hsiao A. Radiol Artif Intell. 2021 Nov 10;4(2):e210160. doi: 10.1148/ryai.2021210160. eCollection 2022 Mar. PMID: 35391767

Comparative efficacy of an optimal exam between ultrasound versus abbreviated MRI for HCC screening in NAFLD cirrhosis: A prospective study. Huang DQ, Fowler KJ, Liau J, Cunha GM, Louie AL, An JY, Bettencourt R, Jung J, Gitto Z, Hernandez C, Lopez SJ, Gupta H, Sirlin CB, Marks RM, Loomba R. Aliment Pharmacol Ther. 2022 Apr;55(7):820-827. doi: 10.1111/apt.16844. Epub 2022 Feb 28. PMID: 35229334

Automating Scoliosis Measurements in Radiographic Studies with Machine Learning: Comparing Artificial Intelligence and Clinical Reports. Ha AY, Do BH, Bartret AL, Fang CX, Hsiao A, Lutz AM, Banerjee I, Riley GM, Rubin DL, Stevens KJ, Wang E, Wang S, Beaulieu CF, Hurt B. J Digit Imaging. 2022 Jun;35(3):524-533. doi: 10.1007/s10278-022-00595-x. Epub 2022 Feb 11. PMID: 35149938

CNN-based Deformable Registration Facilitates Fast and Accurate Air Trapping Measurements at Inspiratory and Expiratory CT. Hasenstab KA, Tabalon J, Yuan N, Retson T, Hsiao A. Radiol Artif Intell. 2021 Nov 10;4(1):e210211. doi: 10.1148/ryai.2021210211. eCollection 2022 Jan. PMID: 35146437

Automated CNN-Based Analysis Versus Manual Analysis for MR Elastography in Nonalcoholic Fatty Liver Disease: Intermethod Agreement and Fibrosis Stage Discriminative Performance. Cunha GM, Delgado TI, Middleton MS, Liew S, Henderson WC, Batakis D, Wang K, Loomba R, Huss RS, Myers RP, Sirlin CB, Fowler KJ, Hasenstab KA. AJR Am J Roentgenol. 2022 Aug;219(2):224-232. doi: 10.2214/AJR.21.27135. Epub 2022 Feb 2. PMID: 35107306

Pulmonary epithelial-myoepithelial carcinoma (P-EMC) with focal high grade transformation: Molecular and cytologic findings. Charles R, Murray S, Gray E, Hu J. Diagn Cytopathol. 2022 Jun;50(6):E156-E162. doi: 10.1002/dc.24936. Epub 2022 Jan 31. PMID: 35100487

Automated segmentation of multiparametric magnetic resonance images for cerebral AVM radiosurgery planning: a deep learning approach. Simon AB, Hurt B, Karunamuni R, Kim GY, Moiseenko V, Olson S, Farid N, Hsiao A, Hattangadi-Gluth JA. Sci Rep. 2022 Jan 17;12(1):786. doi: 10.1038/s41598-021-04466-3. PMID: 35039538

Inactivated Cowpea Mosaic Virus in Combination with OX40 Agonist Primes Potent Antitumor Immunity in a Bilateral Melanoma Mouse Model. Koellhoffer EC, Mao C, Beiss V, Wang L, Fiering SN, Boone CE, Steinmetz NF. Mol Pharm. 2022 Feb 7;19(2):592-601. doi: 10.1021/acs.molpharmaceut.1c00681. Epub 2022 Jan 3. PMID: 34978197

Evaluation of enzymatic proteoglycan loss and collagen degradation in human articular cartilage using ultrashort echo time-based biomarkers: A feasibility study. Wan L, Cheng X, Searleman AC, Ma YJ, Wong JH, Meyer RS, Du J, Tang G, Chang EY. NMR Biomed. 2022 May;35(5):e4664. doi: 10.1002/nbm.4664. Epub 2021 Dec 13. PMID: 34904305

Integrating plant molecular farming and materials research for next-generation vaccines. Chung YH, Church D, Koellhoffer EC, Osota E, Shukla S, Rybicki EP, Pokorski JK, Steinmetz NF. Nat Rev Mater. 2022;7(5):372-388. doi: 10.1038/s41578-021-00399-5. Epub 2021 Dec 6. PMID: 34900343

What Are the Double Lines of the Fetal Cavum Septi Pellucidi on Ultrasound? Green S, Pretorius DH, Crouch A, Anton T, Jacobs M, Ho Y, Hevner R, Lamale-Smith L. J Ultrasound Med. 2022 Aug;41(8):1907-1914. doi: 10.1002/jum.15867. Epub 2021 Nov 9. PMID: 34751464

Radiologist-supervised Transfer Learning: Improving Radiographic Localization of Pneumonia and Prognostication of Patients With COVID-19. Hurt B, Rubel MA, Masutani EM, Jacobs K, Hahn L, Horowitz M, Kligerman S, Hsiao A. J Thorac Imaging. 2021 Oct 28. doi: 10.1097/RTI.0000000000000618. Online ahead of print. PMID: 34710891

Bleeding with iron deposition and vascular remodelling in subchondral cysts: A newly discovered feature unique to haemophilic arthropathy. Zhou JY, Wong JH, Berman ZT, Lombardi AF, Chang EY, von Drygalski A. Haemophilia. 2021 Sep 19. doi: 10.1111/hae.14417. Online ahead of print. PMID: 34537999

Targeting intra-viral conserved nucleocapsid (N) proteins as novel vaccines against SARS-CoVs. Thura M, Sng JXE, Ang KH, Li J, Gupta A, Hong JM, Hong CW, Zeng Q. Biosci Rep. 2021 Sep 30;41(9):BSR20211491. doi: 10.1042/BSR20211491. PMID: 34519332

Variant allele fraction of genomic alterations in circulating tumor DNA (%ctDNA) correlates with SUV _max in PET scan. Haghighat Jahromi A, Zabel M, Okamura R, Hoh CK, Kurzrock R. Am J Nucl Med Mol Imaging. 2021 Aug 15;11(4):307-312. eCollection 2021. PMID: 34513284

Apparent posterior cerebral artery territory perfusion asymmetry on arterial spin labeling MRI is a common non-pathologic finding in patients with a unilateral fetal posterior cerebral artery. Noorbakhsh A, Farid N, Bolar DS. Neuroradiology. 2021 Aug 30. doi: 10.1007/s00234-021-02794-9. Online ahead of print. PMID: 34459946

Establishment of Patient-derived Succinate Dehydrogenase-deficient Gastrointestinal Stromal Tumor Models For Predicting Therapeutic Response. Yebra M, Bhargava S, Kumar A, Burgoyne AM, Tang CM, Yoon H, Banerjee S, Aguilera J, Cordes T, Sheth V, Noh S, Ustoy R, Li S, Advani SJ, Corless CL, Heinrich MC, Kurzrock R, Lippman SM, Fanta PT, Harismendy O, Metallo C, Sicklick JK. Clin Cancer Res. 2021 Aug 23:clincanres.2092.2021. doi: 10.1158/1078-0432.CCR-21-2092. Online ahead of print. PMID: 34426440

The Pancreatitis Activity Scoring System Predicts Clinical Outcomes in Patients With Infected Pancreatic Necrosis. Thiruvengadam NR, Miranda J, Kim C, Behr S, Arain MA. Pancreas. 2021 Jul 1;50(6):859-866. doi: 10.1097/MPA.0000000000001838. PMID: 34347734

Combining nanomedicine and immune checkpoint therapy for cancer immunotherapy. Boone CE, Wang L, Gautam A, Newton IG, Steinmetz NF. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2021 Jul 22:e1739. doi: 10.1002/wnan.1739. Online ahead of print. PMID: 34296535

Fibrodysplasia ossificans progressiva (FOP) presenting as a rapidly growing non-calcified neck mass. Yamin G, Daghighi S, Mafee M. J Radiol Case Rep. 2021 May 31;15(5):10-16. doi: 10.3941/jrcr.v15i5.4103. eCollection 2021 May. PMID: 34276874

Initial Experience With Formal Near-Peer Mentoring in Radiology Residency. Cheng K, Grabowski C, Chong A, Yen A, Chung CB. Curr Probl Diagn Radiol. 2021 Jun 9:S0363-0188(21)00094-3. doi: 10.1067/j.cpradiol.2021.05.005. Online ahead of print. PMID: 34246507

Placenta Accreta Spectrum Treatment With Intraoperative Multivessel Embolization: the PASTIME protocol. Melber DJ, Berman ZT, Jacobs MB, Picel AC, Conturie CL, Zhang-Rutledge K, Binder PS, Eskander RN, Roberts AC, McHale MT, Ramos GA, Ballas J, Kelly TF. Am J Obstet Gynecol. 2021 Oct;225(4):442.e1-442.e10. doi: 10.1016/j.ajog.2021.07.001. Epub 2021 Jul 7. PMID: 34245679

Association Between Rotator Cuff Tears and Superior Migration of the Humeral Head: An MRI-Based Anatomic Study. Siow MY, Mitchell BC, Hachadorian M, Wang W, Bastrom T, Kent WT, Huang BK, Edmonds EW. Orthop J Sports Med. 2021 Jun 10;9(6):23259671211009846. doi: 10.1177/23259671211009846. eCollection 2021 Jun. PMID: 34179206

Starting a Free Ultrasound Clinic for the Underserved: Considerations and Overcoming Challenges. Tadros A, Manning P, Smitaman E, Chong A, Wang K, Tamayo-Murillo D. Acad Radiol. 2021 Jul;28(7):938-943. doi: 10.1016/j.acra.2021.05.001. Epub 2021 Jun 13. PMID: 34130923

Accurate Prostate Volumes from Manual Calculations-A Comparison of PI-RADS v2 and v2.1 Measurement Techniques. An JY, Fowler KJ. Acad Radiol. 2021 May 30:S1076-6332(21)00169-0. doi: 10.1016/j.acra.2021.03.027. Online ahead of print. PMID: 34078573

Incidental Liver Findings on Cross-sectional Imaging. Searleman AC, Aganovic L, Santillan CS. Radiol Clin North Am. 2021 Jul;59(4):569-590. doi: 10.1016/j.rcl.2021.03.007. PMID: 34053606

Reducing Health Disparities in Radiology Through Social Determinants of Health: Lessons From the COVID-19 Pandemic. Abraham P, Bishay AE, Farah I, Williams E, Tamayo-Murillo D, Newton IG. Acad Radiol. 2021 Jul;28(7):903-910. doi: 10.1016/j.acra.2021.04.006. Epub 2021 May 15. PMID: 34001438

The Roots of Structural Racism in the United States and their Manifestations During the COVID-19 Pandemic. Abraham P, Williams E, Bishay AE, Farah I, Tamayo-Murillo D, Newton IG. Acad Radiol. 2021 Jul;28(7):893-902. doi: 10.1016/j.acra.2021.03.025. Epub 2021 May 12. PMID: 33994077

Automated CT Staging of Chronic Obstructive Pulmonary Disease Severity for Predicting Disease Progression and Mortality with a Deep Learning Convolutional Neural Network. Hasenstab KA, Yuan N, Retson T, Conrad DJ, Kligerman S, Lynch DA, Hsiao A; COPDGene Investigators. Radiol Cardiothorac Imaging. 2021 Apr 8;3(2):e200477. doi: 10.1148/ryct.2021200477. eCollection 2021 Apr. PMID: 33969307

Active Microneedle Administration of Plant Virus Nanoparticles for Cancer in situ Vaccination Improves Immunotherapeutic Efficacy. Boone CE, Wang C, Lopez-Ramirez MA, Beiss V, Shukla S, Chariou PL, Kupor D, Rueda R, Wang J, Steinmetz NF. ACS Appl Nano Mater. 2020 Aug 28;3(8):8037-8051. doi: 10.1021/acsanm.0c01506. Epub 2020 Aug 7. PMID: 33969278

Magnetic resonance elastography biomarkers for detection of histologic alterations in nonalcoholic fatty liver disease in the absence of fibrosis. Qu Y, Middleton MS, Loomba R, Glaser KJ, Chen J, Hooker JC, Wolfson T, Covarrubias Y, Valasek MA, Fowler KJ, Zhang YN, Sy E, Gamst AC, Wang K, Mamidipalli A, Schwimmer JB, Song B, Reeder SB, Yin M, Ehman RL, Sirlin CB. Eur Radiol. 2021 Nov;31(11):8408-8419. doi: 10.1007/s00330-021-07988-6. Epub 2021 Apr 26. PMID: 33899143

Extensive mature cystic teratoma in the pelvis of an adult male patient mimicking a prostatic abscess. Alhumayed M, Liau J. Radiol Case Rep. 2021 Apr 9;16(6):1343-1347. doi: 10.1016/j.radcr.2021.03.011. eCollection 2021 Jun. PMID: 33897926

Rosai-Dorfman-Destombes (RDD) disease presenting as palindromic rheumatism. Haghighat Jahromi A, Goodman AM, Hoh CK. BMC Med Imaging. 2021 Apr 15;21(1):72. doi: 10.1186/s12880-021-00596-2. PMID: 33858362

Assessment of Motor Dysfunction with Virtual Reality in Patients Undergoing [ ¹²³I]FP-CIT SPECT/CT Brain Imaging. Vu JP, Yamin G, Reyes Z, Shin A, Young A, Litvan I, Xie P, Obrzut S. Tomography. 2021 Mar 26;7(2):95-106. doi: 10.3390/tomography7020009. PMID: 33810475

Repeatability and accuracy of various region-of-interest sampling strategies for hepatic MRI proton density fat fraction quantification. Hong CW, Cui JY, Batakis D, Xu Y, Wolfson T, Gamst AC, Schlein AN, Negrete LM, Middleton MS, Hamilton G, Loomba R, Schwimmer JB, Fowler KJ, Sirlin CB. Abdom Radiol (NY). 2021 Jul;46(7):3105-3116. doi: 10.1007/s00261-021-02965-5. Epub 2021 Feb 20. PMID: 33609166

Quantification of the Hemodynamic Changes of Cirrhosis with Free-Breathing Self-Navigated MRI. Brunsing RL, Brown D, Almahoud H, Kono Y, Loomba R, Vodkin I, Sirlin CB, Alley MT, Vasanawala SS, Hsiao A. J Magn Reson Imaging. 2021 May;53(5):1410-1421. doi: 10.1002/jmri.27488. Epub 2021 Feb 16. PMID: 33594733

Time-restricted feeding normalizes hyperinsulinemia to inhibit breast cancer in obese postmenopausal mouse models. Das M, Ellies LG, Kumar D, Sauceda C, Oberg A, Gross E, Mandt T, Newton IG, Kaur M, Sears DD, Webster NJG. Nat Commun. 2021 Jan 25;12(1):565. doi: 10.1038/s41467-020-20743-7. PMID: 33495474

Duplicate inferior vena cava complicating the evaluation of primary aldosteronism. Spurzem GJ, Taddonio MA, Rubenzik TT, Bouvet M. BMJ Case Rep. 2021 Jan 18;14(1):e240093. doi: 10.1136/bcr-2020-240093. PMID: 33462066

CNN color-coded difference maps accurately display longitudinal changes in liver MRI-PDFF. Hasenstab K, Cunha GM, Ichikawa S, Dehkordy SF, Lee MH, Kim SJ, Schlein A, Covarrubias Y, Sirlin CB, Fowler KJ. Eur Radiol. 2021 Jul;31(7):5041-5049. doi: 10.1007/s00330-020-07649-0. Epub 2021 Jan 15. PMID: 33449180

Quantification of hemodynamics of cerebral arteriovenous malformations after stereotactic radiosurgery using 4D flow magnetic resonance imaging. Srinivas S, Retson T, Simon A, Hattangadi-Gluth J, Hsiao A, Farid N. J Magn Reson Imaging. 2021 Jun;53(6):1841-1850. doi: 10.1002/jmri.27490. Epub 2020 Dec 22. PMID: 33354852

Identifying the axillary nerve during shoulder surgery: an anatomic study using advanced imaging. Hachadorian ME, Mitchell BC, Siow MY, Wang W, Bastrom T, Sullivan TB, Huang BK, Edmonds EW, Kent WT. JSES Int. 2020 Jul 25;4(4):987-991. doi: 10.1016/j.jseint.2020.06.011. eCollection 2020 Dec. PMID: 33345245

Diagnosis, Staging, and Patient Selection for Locoregional Therapy to Treat Hepatocellular Carcinoma. Berman ZT, Newton I. Semin Intervent Radiol. 2020 Dec;37(5):441-447. doi: 10.1055/s-0040-1719185. Epub 2020 Dec 11. PMID: 33328699